The couple will apparently file divorce papers in the LA County Superior Court early next week, TMZ reported.
The website said German supermodel Heidi, 38, will cite 'irreconcilable differences' as the reason for the split.
Is it over? Heidi Klum and Seal are to file for divorce after six years of marriage, according to reports
The reports have shocked fans of the couple who often make public displays of affection at red carpet events, and are a picture of happiness with their four children.
The couple or their management are yet to comment on the reports.
They were last seen together on December 27, with Heidi tweeting a picture of her and her husband smiling against the backdrop of mountains in Aspen, Colorado.
They met in 2004 while Heidi was pregnant with her daughter Leni, now seven, with Italian businessman Flavio Briatore.
London-born crooner Seal, 48, was present for Leni's birth and later adopted her.
He proposed on December 23, 2004, in an igloo he had built on a glacier in Whistler, British Columbia.
Happy: The couple were last seen together on December 27, with Heidi tweeting this picture of them on holiday in Aspen, Colorado
Happy families: The couple have four children, Leni, seven, Henry, six, Johan, five and Lou, two